Spore is available for Microsoft Windows XP and Vista and Mac OS X. Spinoff games are available for the Nintendo DS (Spore Creatures) and the iPhone (Spore Origins). Spore creator Will Wright also has a Wii Spore spinoff in the works that will be a complete re-working of the game rather than being ported over from its PC counterparts.

Though there hasn't been much talk about it, expansions to the Xbox 360 and PS3 are currently under serious consideration. Will Wright has stated that these spinoffs will only feature certain aspects of the PC game rather than exact clones in order to take advantage of each platform's strengths.